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Absolute Contraindications Severe cardiovascular disease (heart failure, recent myocardial infarction) Uncontrolled hypertension or hypotension History of severe peptide allergies Pregnancy and breastfeeding (unknown fetal effects) Severe renal or hepatic impairment (unknown clearance mechanisms) Managing Side Effects Given PE-22-28's research-only status, side effect management strategies remain theoretical and based on general peptide therapy principles
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